Dose Analysis of BNCT Treatment Method for Rhabdomyosarcoma in the Head and Neck Regions Based on PHITS Code
AJSTD 35(3)
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Keywords

BNCT
Boron dose
Kartini Reactor
PHITS
Rhabdomyosarcoma

Abstract

 The objectives of this research were to find (1) the optimum boron dose for treating rhab- domyosarcoma in the head and neck regions and (2) the effective irradiation time to treat rhab- domyosarcoma in the head and neck regions. This research used the particle and heavy ions transport code system (PHITS) to simulate the neutron source and BNCT doses. The neutron source used was Kartini Reactor. The simulation was carried out by creating the geometry of cancer tissue in the head and neck regions. Boron concentration variance was 30, 35, 40, 45, and 50 µg/g tissue. The output of PHITS was a neutron flux and neutron dose. The neutron flux value was used to acquire the alpha dose, proton dose, and gamma dose inside the tissue. The results showed that (1) the optimum boron dose for treating rhabdomyosarcoma in the head and neck regions was 50 µg/g tissue and (2) the effective irradiation time was 7 hours and 4 minutes, which was acquired with a boron concentration of 50 µg/g tissue. The higher the boron concentration level, the higher the dose rate, the quicker the irradiation time, and the lower the radiation dose received by healthy tissues.

https://doi.org/10.29037/ajstd.521
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References

Aihara T, Morita N, Kamitani N, Kumada H, Ono K, HiratsukaJ, Harada T. 2014. BNCT for advanced or recurrent head and neck cancer. Appl Radiat Isot. 88:12–15. doi:10.101 6/j.apradiso.2014.04.007.

Arrozaqi MIM. 2013. Perancangan kolimator di beam port tembus reaktor kartini untuk boron neutron capture therapy [Design of collimator in the radial piercing beam port of Kartini Reactor for boron neutron capture therapy]. Universitas Gadjah Mada. doi:10.1007/s133 98-014-0173-7.2.

Barth RF, H Vicente MG, Harling OK, Kiger W, Riley KJ, Binns PJ, Wagner FM, Suzuki M, Aihara T, Kato I, Kawa- bata S. 2012. Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer. Radiat Oncol. 7(1):146. doi:10.1186/1748-717X-7-146.

Cristy M, Eckerman KF. 1987. Specific absorbed fractions of energy at various ages from internal photon sources: 7, Adult male. Technical Report ORNL/TM–8381/V7. Oak Ridge National Lab.. Oak Ridge.

El Demellawy D, McGowan-Jordan J, de Nanassy J, Cher-netsova E, Nasr A. 2017. Update on molecular find- ings in rhabdomyosarcoma. Pathology. 49(3):238–246. doi:10.1016/j.pathol.2016.12.345.

Lee RJ, Lee KK, Lin T, Arshi A, Lee SA, Christensen RE. 2017. Rhabdomyosarcoma of the head and neck: impact of demographic and clinicopathologic factors on survival. Oral Surg Oral Med Oral Pathol Oral Radiol. 124(3):271–279. doi:10.1016/j.oooo.2017.05.507.

Miaskowski C, Paul SM, Mastick J, Schumacher M, Con-ley YP, Smoot B, Abrams G, Kober KM, Cheung S, Henderson-Sabes J, Chesney M, Mazor M, Wallhagen M, Levine JD. 2018. Hearing loss and tinnitus in sur- vivors with chemotherapy-induced neuropathy. Eur J Oncol Nurs. 32:1–11. doi:10.1016/j.ejon.2017.10.006.

Moss RL. 2014. Critical review, with an optimistic outlook,on boron neutron capture therapy (BNCT). Appl Radiat Isot. 88:2–11. doi:10.1016/j.apradiso.2013.11.109.

[NIST] National Institute of Standards and Technology. nd.Compositions of Materials used in STAR Databases. Https://physics.nist.gov/cgi-bin/Star/compos.pl. ht tps://physics.nist.gov/cgi-bin/Star/compos.pl.

Radzikowska J, Kukwa W, Kukwa A, Czarnecka A, Krzeski A. 2015. Review rhabdomyosarcoma of the head and neck in children. Współczesna Onkol. 2:98–107. doi:10.5114/wo.2015.49158.

Reilly BK, Kim A, Peña MT, Dong TA, Rossi C, Murnick JG, Choi SS. 2015. Rhabdomyosarcoma of the head and neck in children: review and update. Int J Pediatr Otorhinolaryngol. 79(9):1477–1483. doi:10.1016/j.ijpo rl.2015.06.032.

Rosidah S, Sardjono Y, Sumardi Y. 2017. Dose analyze of boron neutron capture therapy (BNCT) at skin can- cer melanoma using MCNPX with neutron source from thermal column of Kartini Reactor. Indones J Phys Nucl Appl. 2(3):111. doi:10.24246/ijpna.v2i3.111-123.

Sardjono Y, Widodo S, Irhas I, Tantawy H. 2016. A design of boron neutron capture therapy for cancer treatment in Indonesia. Indones J Phys Nucl Appl. 1(1):1. doi:10.24246 /ijpna.v1i1.1-13.

Sauerwein W, Wittig A, Moss R, Nakagawa Y, editors. 2012.Neutron Capture Therapy. Berlin, Heidelberg: Springer. doi:10.1007/978-3-642-31334-9.

Smith S, Prewett S. 2017. Principles of chemotherapy and radiotherapy. Obstet Gynaecol Reprod Med. 27(7):206–212. doi:10.1016/j.ogrm.2017.04.006.

Stewart B, Wild C, editors. 2014. World cancer report 2014.International Agency for Research on Cancer.

Winocur G, Henkelman M, Wojtowicz JM, Zhang H, Binns MA, Tannock IF. 2012. The effects of chemotherapy on cognitive function in a mouse model: A prospective study. Clin Cancer Res. 18(11):3112–3121. doi:10.1158/10 78-0432.CCR-12-0060.
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